Past Forum: 2016
Summary
The 2016 World Medical Innovation Forum focused on cancer and opened with a wave of young investigators highlighting promising developments in a series of rapid-fire presentations. Recurring themes of the First Look session included the use of RNA in-situ hybridization (RNA-ISH) as a diagnostic tool, liquid biopsies for exosome analysis, and precision medicine approaches to patient care. Multiple presentations also highlighted the capabilities of the AMIGO suite at Brigham and Women’s Hospital, which uses intraoperative imaging to guide precise localization and analysis of patient tumors during surgery.
Attendees then had the chance to liaise with established Harvard Medical School faculty over lunch during the Discovery Café session, which paired interested Forum attendees with renowned leaders in their respective fields. Nearly 30 faculty members covered topics such as immunotherapy, diagnostics, therapy resistance, and the potential of CRISPR for research and therapeutics.
The Forum plenary opened with David Torchiana, MD, CEO and Anne Klibanski MD, Chief Academic Officer of Partners HealthCare, who welcomed an audience representing more than two dozen countries and introduced a program filled with high-caliber speakers and hot topics including immunotherapy, epigenetics, and bioinformatics. They emphasized the importance of collaboration to accomplish the goal of providing better care and support to cancer patients and their families and noted that the “engine of innovation is running better than ever” as we seek to push the boundaries of the many diseases collectively known as cancer.
Additional Highlights
- Remarks from Greg Simon, Executive Director, The White House Moonshot Initiative
- Executive Fireside Chats with health care leaders: Richard Gonzalez, CEO of AbbVie, Robert Bradway, CEO of Amgen, Giovanni Caforio, MD, CEO, Bristol-Myers Squibb, Kathy Giusti, Founder MMRF, and Joseph Jimenez, CEO, Novartis
- War or Moonshot: Where do we stand? Nancy Snyderman, MD, Medical Advisor at GE Healthymagination, sat down with Monica Bertagnolli, MD, Chief of the Division of Surgical Oncology at Brigham and Women’s Hospital, and Daniel Haber, MD, PhD, Director of the MGH Cancer Center to discuss what’s to come in a new era of cancer research and care. Panelists were tasked with advising on whether cancer research and care over the next decade will be a war or a moonshot. They agreed on both perspectives – a war because, from a patient perspective, it is a personal battle against disease and we must come together as an army to combat the disease and work effectively towards a cure, and a moonshot because progress in cancer happens with huge steps forward and reflects the combined efforts of a large group of people working toward a common goal, much like landing on the moon.
- Sessions moderated by leading broadcast journalists, experienced healthcare executives and venture capital leaders, including: Nancy Snyderman, MD, Medical Advisor at GE Healthymagination, CNBC Biotech and Pharma Reporter Meg Tirrell, Robert Tepper, MD of Third Rock Ventures, Sue Sigel, CEO, GE Ventures and Healthymagination, Thomas Lynch, CEO, MGPO, Sheila Dharmarajan, Head of BD, Zelnick Media Capital, Caroline Chen, Reporter, Bloomberg Business, Mallika Marshall, MD, Health Reporter, WBZ-TV/CBS Boston
- Astellas Pharma announced the launch of the inaugural C3 Prize™
Partners HealthCare announced the Disruptive Dozen, 12 technologies predicted to have the greatest impact on cancer care in the next decade. The main stage was filled with 12 influential leaders in cancer research and clinical care from Massachusetts General Hospital, Brigham and Women’s Hospital and Dana-Farber Cancer Institute, who came together for an exciting and insightful discussion around these state-of-the-art medical technologies and what they mean for the future of the field.
A full recap of the 2016 event is located here: worldmedicalinnovation.org/past-forums
Keynoters
Joseph Jimenez
CEO, Novartis
Robert Bradway
CEO, Amgen
Robert Mulroy
CEO, Merrimack Pharmaceuticals
Briggs Morrison, MD
CEO, Syndax Pharmaceuticals
David Lee
CEO, Lumicell
Marc de Garidel
Chairman and CEO, Ipsen
Paul Hudson
President, AstraZeneca US, Executive Vice President,
AstraZeneca North America
David Torchiana, MD
CEO, Partners HealthCare
Daniel Haber MD, PhD
Director, Massachusetts General Hospital Cancer Center, Kurt J. Isselbacher / Peter D. Schwartz Professor of Oncology, Harvard Medical School
Glenn Dranoff, MD
Global Head of Exploratory Immuno-Oncology, Novartis Institutes for Biomedical Research
Christopher Viehbacher
Managing Partner, Gurnet Point Capital
Henri Termeer
Jean-François Formela, MD
Partner, Atlas Venture
Bob Tepper, MD
Partner, Third Rock Ventures
Kathy Giusti
Founder and Executive Chairman, MMRF
Giovanni Caforio, MD
CEO, Bristol-Myers Squibb
Richard Gonzalez
CEO, AbbVie
Michael Pellini, MD
CEO, Foundation Medicine
David Schenkein, MD
CEO, Agios Pharmaceuticals
Bruno Strigini
President, Novartis Oncology
William Hait, MD, PhD
Global Head, Janssen R&D;, J&J;
Gary Reedy
CEO, American Cancer Society
Thomas Lynch, MD
CEO, Mass General Physician’s Organization
Monica Bertagnolli, MD
Chief, Division of Surgical Oncology, Brigham and Women’s Hospital, Professor of Surgery, Harvard Medical School
Judy Salerno, MD
CEO, Susan G. Komen for the Cure
William Sellers, MD
Vice President and Global Head of Oncology, Novartis Institutes for BioMedical Research
Nancy Snyderman, MD
Medical Advisor, GE Healthymagination
Amir Nashat, PhD
Managing Partner, Polaris Partners
Jim Robinson
President, Americas Operations, Astellas
Francis Cuss, MD
Executive Vice President and Chief Scientific Officer, R&D;, Bristol-Myers Squibb
Panels
Day One: Monday, April 25, 2016
First Look: The Next Wave of Cancer Breakthroughs
Discovery Café: Enjoy Lunch with Top Cancer Leadership from across Partners HealthCare
Forum Opening and Announcements
- Anne Klibanski, MD
Chief Academic Officer, Partners HealthCare; Laurie Carrol Guthart Professor of Medicine, Harvard Medical School - David Torchiana, MD
CEO, Partners HealthCare
A War or Moonshot: Where Do We Stand?
- Nancy Snyderman, MD
Medical Advisor, GE Healthymagination - Monica Bertagnolli, MD
Chief, Division of Surgical Oncology, BWH
Professor of Surgery, Harvard Medical School - Daniel Haber, MD, PhD
Director, MGH Cancer Center
Kurt J. Isselbacher/Peter D. Schwartz Professor of Oncology, Harvard Medical School
Creating a Disruptive Cancer Pipeline
- Robert Tepper, MD
Partner, Third Rock Ventures
Adjunct Professor, Harvard Medical School - James Bradner, MD
President, Novartis Institutes for BioMedical Research - George Demetri, MD
Director, Center for Sarcoma and Bone Oncology
Senior Vice President for Experimental Therapeutics, Institute Physician, DFCI - Keith Flaherty, MD
Director, Clinical Research, MGH Cancer Center
Associate Professor of Medicine, Harvard Medical School - Sean Harper, MD
Executive Vice President, Research and Development, Amgen
Curative Therapies: The Economics of Game Changing Science
- Gregg Meyer, MD
Chief Clinical Officer, Partners HealthCare - Sue Siegel, CEO
GE Ventures and Healthymagination - Troyen Brennan, MD
Executive Vice President and CMO, CVS Health - Paul Hudson
President, AstraZeneca US
Executive Vice President, AstraZeneca North America - Betsy Nabel, MD
President, Brigham and Women’s Hospital
Professor of Medicine, Harvard Medical School - Gary Reedy, CEO
American Cancer Society - Peter Slavin, MD
President, Massachusetts General Hospital
Professor of Healthcare Policy, Harvard Medical School
- Thomas Lynch, MD
CEO, Mass General Physician's Organization - Francis Cuss, MD
Executive Vice President and Chief Scientific Officer, R&D, Bristol-Myers Squibb - Peter Lebowitz, MD, PhD
Global Therapeutic Area Head, Oncology, Janssen R&D , J&J - Briggs Morrison, MD
CEO, Syndax Pharmaceuticals - Alessandro Riva, MD
Global Head, Oncology Development and Medical Affairs, Novartis Oncology - Phil Rowlands, PhD
Interim Head, Oncology, Therapeutic Area Unit, Takeda
Early Detection and Prevention of Cancer
- David Louis, MD
Pathologist-in-Chief, MGH
Benjamin Castleman Professor of Pathology, Harvard Medical School - Andy Chan, MD
Program Director, Gastroenterology Training Program, MGH
Associate Professor of Medicine, Harvard Medical School - William Hait, MD, PhD
Global Head, Janssen Research & Development , J&J - Krishna Kumar
CEO, Emerging Businesses, Philips - Massimo Loda, MD
Senior Pathologist, Principal Investigator, BWH, DFCI
Professor, Department of Pathology, Harvard Medical School
Innovation Break: Announcing the C³ Prize from Astellas Oncology and the World Medical Innovation Forum
Ropes & Gray Dinner Program Fireside Chat: Richard Gonzalez, CEO, AbbVie
- Edward Lawrence
Retired Partner, Ropes & Gray - Nancy Snyderman, MD
Medical Advisor, GE Healthymagination - Richard Gonzalez
CEO, AbbVie
Day Two: Tuesday, April 26, 2016
- Sheila Dharmarajan
Head of Business Development, Zelnick Media Capital - Newton Crenshaw
Vice President of North America Oncology, Eli Lilly and Company - Marc de Garidel
Chairman and CEO, Ipsen - Gillian Leng, MD
Deputy Chief Executive, Director of Health and Social Care, National Institute for Health and Care Excellence - James Robinson
President, Americas Operations, Astellas - Bruno Strigini
President, Novartis Oncology
Epigenetics and Novel Cancer Targets
- Pat Fortune, PhD
Senior Market Sector Leader, Partners Innovation - Robert Copeland, PhD
President of Research and Chief Scientific Officer, Epizyme - Keith Dionne, PhD
CEO, Constellation Pharmaceuticals, Inc. - Cigall Kadoch, PhD
Assistant Professor, DFCI, Harvard Medical School - Jeannie Lee, MD, PhD
Professor of Genetics, MGH - Nancy Simonian, MD
CEO, Syros Pharmaceuticals - Johnathan Whetstine, PhD
Tepper Family MGH Research Scholar,
Associate Professor of Medicine, Harvard Medical School
Fireside Chat: Robert Bradway, CEO, Amgen
- Cathy Minehan
Dean, School of Management, Simmons College - Caroline Chen
Reporter, Bloomberg Business - Robert Bradway
CEO, Amgen
Immunotherapy I: Checkpoint Activation and Cancer Vaccines
- Nir Hacohen, PhD
Immunologist, MGH Center for Immunology and Inflammatory Diseases, MGH Research Scholar, Associate Professor, Medicine, Harvard Medical School - Thomas Daniel, MD
Chairman, Celgene Research - Glenn Dranoff, MD
Global Head of Exploratory Immuno-Oncology, Novartis Institutes for Biomedical Research - Robert Mulroy
President and CEO, Merrimack Pharmaceuticals - David Reese, MD
Senior Vice President, Translational Sciences, Amgen - Scott Rodig, MD, PhD
Associate Professor, BWH - Arlene Sharpe, MD, PhD
Leader, Cancer Immunology, BWH, DFCI, George Fabyan Professor of Comparative Pathology, Harvard Medical School
Fireside Chat: Andy Slavitt, Acting Administrator, CMS
- David Torchiana, MD
CEO, Partners HealthCare - Meg Tirrell
Biotech and Pharma Reporter, CNBC - Andy Slavitt
Acting Administrator, CMS
Fireside Chat: Giovanni Caforio, MD, CEO, Bristol-Myers Squibb
- Thomas Lynch, MD
CEO, Mass General Physician's Organization - Meg Tirrell
Biotech and Pharma Reporter, CNBC - Giovanni Caforio, MD
CEO, Bristol-Myers Squibb
Fireside Chat: Patients Driving Innovation
- Nancy Snyderman, MD
Medical Advisor, GE Healthymagination - Kathy Giusti
Founder, Multiple Myeloma Research Foundation and Multiple Myeloma Research Consortium
Immunotherapy II: Cell Based Therapies
- David Fisher, MD, PhD
Chief, Dermatology Service, Director, Melanoma Program, Director, Cutaneous Biology Research Center, MGH Cancer Center
Edward Wigglesworth Professor of Dermatology, Harvard Medical School - Usman (Oz) Azam, MD
Global Head, Cell & Gene Therapies Unit, Novartis - Mark Frohlich, MD
Executive Vice President, Portfolio Strategy, Juno Therapeutics - Marcela Maus, MD, PhD
Director of Cellular Immunotherapy, MGH, Assistant Professor, Harvard Medical School - Chuck Wilson, PhD
CEO, Unum Therapeutics
Financing Breakthrough Cancer Companies
- Roger Kitterman
Managing Partner, Partners Innovation Fund, Partners Innovation - Meg Tirrell
Biotech and Pharma Reporter, CNBC - Jean-François Formela, MD
Partner, Atlas Ventures - Jonathan Leff
Partner, Deerfield Management - Amir Nashat, PhD
Managing Partner, Polaris Partners - Christopher Viehbacher
Managing Partner, Gurnet Point Capital
- Jonathan Behr, PhD
Market Sector Leader, Partners Innovation - Jay Loeffler, MD
Chair, Radiation Oncology, MGH - Daphne Haas-Kogan, MD
Chair, Department of Radiation Oncology, BWH, DFCI
Professor of Radiation Oncology, Harvard Medical School - Theodore Hong, MD
Director, Gastrointestinal Radiation Oncology, MGH
Associate Professor of Radiation Oncology, Harvard Medical School - Joseph Jachinowski
CEO, Mevion Medical Systems - Dow Wilson
CEO, Varian Medical Systems
Breakthrough Devices to Treat Cancer
- Monica Bertagnolli, MD
Chief, Division of Surgical Oncology, BWH
Professor of Surgery, Harvard Medical School - Antonio Chiocca, MD, PhD
Chairman, Neurosurgery, BWH
Professor of Surgery, Harvard Medical School - Maurice Ferre
MD, CEO, Insightec - David Lee
CEO, Lumicell - Amy Pollack, MD
Chief Medical Officer and Vice President of Global Medical Affairs for the Early Technologies Business Group/Minimally Invasive Technology Innovations (MITG), Medtronic - Ralph Weissleder, MD, PhD
Director, Center for Systems Biology, MGH
Professor, Radiology and Systems Biology, Harvard Medical School
Study Designs to Meet the Challenges of Personalized Cancer Medicine
- Pat Fortune, PhD
Senior Market Sector Leader, Partners Innovation - Gideon Gil
Managing Editor, STAT - Julia Beaver, MD
Acting Clinical Team Leader, Division of Oncology Products 1, CDER, FDA - Maria Koehler, MD, PhD
Vice President, Strategy, Innovation and Collaborations, Pfizer Oncology Business Unit - Deborah Schrag, MD
Chief, Division of Population Sciences, Medical Oncology, DFCI
Professor of Medicine, Harvard Medical School - Mike Vasconcelles, MD
CMO, Unum Therapeutics
Surviving Cancer: New Realities, New Needs
- Trung Do
Executive Director, Business Development, Partners Innovation - Tim Ferris, MD
Senior Vice President of Population Health Management, PHS - Jani Ahonala
CEO, Noona Healthcare - Don Dizon, MD
Clinical Co-Director, Gynecologic Oncology, Founder and Director, The Oncology Sexual Health Clinic, MGH
Associate Professor of Medicine, Harvard Medical School - Ann Partridge, MD
Director, Adult Survivorship Program, Program for Young Women with Breast Cancer, DFCI
Associate Professor of Medicine, Harvard Medical School - Claire Thom
Senior Vice President, Global Oncology Development, Astellas
Wednesday, April 27, 2016
Combination Cancer Therapies: Drug Resistance and Therapeutic Index
- Jens Eckstein, PhD
President, SR One - Kenneth Anderson, MD
Director, Jerome Lipper Multiple Myeloma Center, Kraft Family Professor of Medicine, Harvard Medical School - Jeffrey Engelman, MD, PhD
Director, Thoracic Oncology and Director, Molecular Therapeutics, Medical Oncology, MGH
Laurel Schwartz Associate Professor of Medicine, Harvard Medical School - Jamie Freedman, MD, PhD
Senior Vice President, Global Clinical Development, Medimmune - David Schenkein, MD
CEO, Agios Pharmaceuticals - William Sellers, MD
Vice President and Global Head of Oncology, Novartis Institutes for BioMedical Research
Fireside Chat: Joseph Jimenez, CEO, Novartis
- Gregg Meyer, MD
Chief Clinical Officer, Partners HealthCare - Joseph Jimenez
CEO, Novartis
Cancer Diagnostics: New Uses, New Reimbursements?
- Jeffrey Golden, MD
Chair of Pathology, Brigham and Women’s Hospital
Ramzi S. Cotran Professor of Pathology, Harvard Medical School - Helmy Eltoukhy, PhD
CEO, Guardant Health, Inc. - Marc Grodman, MD, CEO
BioReference Laboratories - John Iafrate, MD, PhD
Associate in Pathology, Medical Director, Center for Integrated Diagnostics, MGH
Professor of Pathology, Harvard Medical School - Neal Lindeman, MD
Associate Pathologist, BWH
Associate Professor, Pathology, Harvard Medical School - Michael Pellini, MD
CEO, Foundation Medicine - Risa Stack, PhD
General Manager, New Business Creation, GE Ventures
New Philanthropy: Patients Driving Innovation
- Scott Sperling
Co-President Thomas H. Lee Partners - Mallika Marshall, MD
Health Reporter, WBZ-TV/CBS Boston - Louis DeGennaro, PhD
President and CEO, The Leukemia & Lymphoma Society - Judy Salerno, MD
President and CEO, Susan G. Komen for the Cure - Billy Starr
Founder and Executive Director, Pan-Mass Challenge
- Monica Bertagnolli, MD
Chief, Division of Surgical Oncology, BWH
Professor of Surgery, Harvard Medical School - Daniel Haber, MD, PhD
Director, MGH Cancer Center, Kurt J. Isselbacher/Peter D. Schwartz Professor of Oncology, Harvard Medical School
Forum Closing
- Anne Klibanski, MD
Chief Academic Officer, Partners HealthCare
Laurie Carrol Guthart Professor of Medicine, Harvard Medical School
Sponsors